Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases

Open Access

Peer-reviewed

Research Article

Priscila O. de Giuseppe,

Affiliation Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo, Brazil
⨯
Nadia H. Martins,

Affiliation Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo, Brazil
⨯
Andreia N. Meza,

Affiliation Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo, Brazil
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Camila R. dos Santos,

Affiliation Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo, Brazil
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Humberto D’Muniz Pereira,

Affiliation Instituto de Física de São Carlos, Grupo de Cristalografia, Universidade de São Paulo, São Carlos, São Paulo, Brazil
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Mario T. Murakami

* E-mail: mario.murakami@lnbio.org.br

Affiliation Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo, Brazil
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Carbon
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Crystal structure
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Hydrogen bonding
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Nucleosides
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Phosphates
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Adenosine
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Catalysis
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Gene therapy
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