Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

Marina Kovalenko; Ella Dragileva; Jason St. Claire; Tammy Gillis; Jolene R. Guide; Jaclyn New; Hualing Dong; Raju Kucherlapati; Melanie H. Kucherlapati; Michelle E. Ehrlich; Jong-Min Lee; Vanessa C. Wheeler

doi:10.1371/journal.pone.0044273

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Open Access

Peer-reviewed

Research Article

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

Marina Kovalenko ,

Contributed equally to this work with: Marina Kovalenko, Ella Dragileva

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Ella Dragileva ,

Contributed equally to this work with: Marina Kovalenko, Ella Dragileva

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jason St. Claire,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Tammy Gillis,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jolene R. Guide,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Jaclyn New,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Hualing Dong,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Raju Kucherlapati,

Affiliation Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
⨯
Melanie H. Kucherlapati,

Affiliation Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
⨯
Michelle E. Ehrlich,

Affiliation Farber Institute for Neurosciences, Thomas Jefferson University College of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Jong-Min Lee,

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Vanessa C. Wheeler

* E-mail: Wheeler@chgr.mgh.harvard.edu

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯

Msh2 Acts in Medium-Spiny Striatal Neurons as an Enhancer of CAG Instability and Mutant Huntingtin Phenotypes in Huntington’s Disease Knock-In Mice

Marina Kovalenko,
Ella Dragileva,
Jason St. Claire,
Tammy Gillis,
Jolene R. Guide,
Jaclyn New,
Hualing Dong,
Raju Kucherlapati,
Melanie H. Kucherlapati,
Michelle E. Ehrlich

Published: September 7, 2012
https://doi.org/10.1371/journal.pone.0044273

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