Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

Lei Wang; Shengyan Xiang; Kendra A. Williams; Huiqin Dong; Wenlong Bai; Santo V. Nicosia; Saadi Khochbin; Gerold Bepler; Xiaohong Zhang

doi:10.1371/journal.pone.0044265

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Open Access

Peer-reviewed

Research Article

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

Lei Wang ,

Contributed equally to this work with: Lei Wang, Shengyan Xiang

Affiliation Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
⨯
Shengyan Xiang ,

Contributed equally to this work with: Lei Wang, Shengyan Xiang

Affiliation Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
⨯
Kendra A. Williams,

Affiliation Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
⨯
Huiqin Dong,

Affiliation Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America
⨯
Wenlong Bai,

Affiliations Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America, Program of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Santo V. Nicosia,

Affiliations Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America, Experimental Therapeutics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Saadi Khochbin,

Affiliation French National Institute of Health and Medical Research, The Albert Bonniot Institute, Grenoble, France
⨯
Gerold Bepler ,

* E-mail: beplerg@karmanos.org (GB); xzhang1@health.usf.edu (XZ)

Affiliation Department of Oncology, Karmanos Cancer Institute, Detroit, Michigan, United States of America
⨯
Xiaohong Zhang

* E-mail: beplerg@karmanos.org (GB); xzhang1@health.usf.edu (XZ)

Affiliations Department of Pathology and Cell Biology, University of South Florida, Morsani College of Medicine, Tampa, Florida, United States of America, Program of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

Lei Wang,
Shengyan Xiang,
Kendra A. Williams,
Huiqin Dong,
Wenlong Bai,
Santo V. Nicosia,
Saadi Khochbin,
Gerold Bepler,
Xiaohong Zhang

Published: September 5, 2012
https://doi.org/10.1371/journal.pone.0044265

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