Random Mutagenesis MAPPIT Analysis Identifies Binding Sites for Vif and Gag in Both Cytidine Deaminase Domains of Apobec3G

Isabel Uyttendaele; Delphine Lavens; Dominiek Catteeuw; Irma Lemmens; Celia Bovijn; Jan Tavernier; Frank Peelman

doi:10.1371/journal.pone.0044143

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Peer-reviewed

Research Article

Random Mutagenesis MAPPIT Analysis Identifies Binding Sites for Vif and Gag in Both Cytidine Deaminase Domains of Apobec3G

Isabel Uyttendaele,

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Delphine Lavens,

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Dominiek Catteeuw,

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Irma Lemmens,

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Celia Bovijn,

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Jan Tavernier ,

Contributed equally to this work with: Jan Tavernier, Frank Peelman

* E-mail: jan.tavernier@vib-ugent.be (JT); frank.peelman@vib-ugent.be (FP)

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯
Frank Peelman

Contributed equally to this work with: Jan Tavernier, Frank Peelman

* E-mail: jan.tavernier@vib-ugent.be (JT); frank.peelman@vib-ugent.be (FP)

Affiliations Department of Medical Protein Research, VIB, Ghent, Belgium, Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
⨯

Random Mutagenesis MAPPIT Analysis Identifies Binding Sites for Vif and Gag in Both Cytidine Deaminase Domains of Apobec3G

Isabel Uyttendaele,
Delphine Lavens,
Dominiek Catteeuw,
Irma Lemmens,
Celia Bovijn,
Jan Tavernier,
Frank Peelman

Published: September 10, 2012
https://doi.org/10.1371/journal.pone.0044143

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Mutagenesis
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Transfection
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Substitution mutation
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Luciferase
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Protein interactions
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Dimerization
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Protein-protein interactions
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Polymerase chain reaction
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