Allele Loss and Down-Regulation of Heparanase Gene Are Associated with the Progression and Poor Prognosis of Hepatocellular Carcinoma

Guo-Liang Huang; Bin-Kui Li; Mei-Yin Zhang; Rong-Rong Wei; Yun-Fei Yuan; Ming Shi; Xiao-Qian Chen; Long Huang; Hui-Zhong Zhang; Wanqing Liu; Bi-Jun Huang; Honghua Li; Xiao-Feng Zheng; Xian-Rong Luo; Hui-Yun Wang

doi:10.1371/journal.pone.0044061

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Open Access

Peer-reviewed

Research Article

Allele Loss and Down-Regulation of Heparanase Gene Are Associated with the Progression and Poor Prognosis of Hepatocellular Carcinoma

Guo-Liang Huang,

Affiliations National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, Guangdong, China
⨯
Bin-Kui Li,

Affiliation Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Mei-Yin Zhang,

Affiliation National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Rong-Rong Wei,

Affiliation National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Yun-Fei Yuan,

Affiliation Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Ming Shi,

Affiliation Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Xiao-Qian Chen,

Affiliation National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Long Huang,

Affiliation National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Hui-Zhong Zhang,

Affiliation Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Wanqing Liu,

Affiliation Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Bi-Jun Huang,

Affiliation National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Honghua Li,

Affiliation Department of Pharmacology, Robert W. Johnson Medical School, UMDNJ, Piscataway, New Jersey, United States of America
⨯
Xiao-Feng Zheng,

Affiliation Department of Pharmacology, Robert W. Johnson Medical School, UMDNJ, Piscataway, New Jersey, United States of America
⨯
Xian-Rong Luo,

Affiliation The 458 Hospital of PLA, Guangzhou, Guangdong, China
⨯
Hui-Yun Wang

* E-mail: wanghyun@mail.sysu.edu.cn

Affiliations National Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, Department of Pharmacology, Robert W. Johnson Medical School, UMDNJ, Piscataway, New Jersey, United States of America
⨯

Allele Loss and Down-Regulation of Heparanase Gene Are Associated with the Progression and Poor Prognosis of Hepatocellular Carcinoma

Guo-Liang Huang,
Bin-Kui Li,
Mei-Yin Zhang,
Rong-Rong Wei,
Yun-Fei Yuan,
Ming Shi,
Xiao-Qian Chen,
Long Huang,
Hui-Zhong Zhang,
Wanqing Liu

Published: August 31, 2012
https://doi.org/10.1371/journal.pone.0044061

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Gene expression
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Single nucleotide polymorphisms
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