Targeted Ubiquitination and Degradation of G-Protein-Coupled Receptor Kinase 5 by the DDB1-CUL4 Ubiquitin Ligase Complex

Open Access

Peer-reviewed

Research Article

Ziyan Wu,

Affiliation The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
⨯
Yuejun Chen ,

* E-mail: yuejunchen@fudan.edu.cn

Affiliation The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
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Tong Yang,

Affiliation The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
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Qinqin Gao,

Affiliation The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
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Man Yuan,

Affiliation The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
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Lan Ma

Affiliation The State Key Laboratory of Medical Neurobiology and Pharmacology Research Center, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China
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Immunoprecipitation
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T cells
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Ubiquitin ligases
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DNA-binding proteins
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Ubiquitination
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Lentivirus
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RNA interference
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Transfection
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