Nicotine Promotes Proliferation of Human Nasopharyngeal Carcinoma Cells by Regulating α7AChR, ERK, HIF-1α and VEGF/PEDF Signaling

Dingbo Shi; Wei Guo; Wangbin Chen; Lingyi Fu; Jingshu Wang; Yung Tian; Xiangsheng Xiao; Tiebang Kang; Wenlin Huang; Wuguo Deng

doi:10.1371/journal.pone.0043898

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Open Access

Peer-reviewed

Research Article

Nicotine Promotes Proliferation of Human Nasopharyngeal Carcinoma Cells by Regulating α7AChR, ERK, HIF-1α and VEGF/PEDF Signaling

Dingbo Shi ,

Contributed equally to this work with: Dingbo Shi, Wei Guo

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Wei Guo ,

Contributed equally to this work with: Dingbo Shi, Wei Guo

Affiliation Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China
⨯
Wangbin Chen,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Lingyi Fu,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Jingshu Wang,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Yung Tian,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Xiangsheng Xiao,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Tiebang Kang,

Affiliation State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China
⨯
Wenlin Huang,

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China, State Key Laboratory of Targeted Therapy Drug of Guangdong, Guangzhou, China
⨯
Wuguo Deng

* E-mail: dengwg@sysucc.org.cn

Affiliations State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China, State Key Laboratory of Targeted Therapy Drug of Guangdong, Guangzhou, China
⨯

Nicotine Promotes Proliferation of Human Nasopharyngeal Carcinoma Cells by Regulating α7AChR, ERK, HIF-1α and VEGF/PEDF Signaling

Dingbo Shi,
Wei Guo,
Wangbin Chen,
Lingyi Fu,
Jingshu Wang,
Yung Tian,
Xiangsheng Xiao,
Tiebang Kang,
Wenlin Huang,
Wuguo Deng

Published: August 31, 2012
https://doi.org/10.1371/journal.pone.0043898

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Nasopharyngeal carcinoma
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Nicotine replacement therapy
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Cell proliferation
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