Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models

Kaipeng Huang; Weihua Liu; Tian Lan; Xi Xie; Jing Peng; Juan Huang; Shaogui Wang; Xiaoyan Shen; Peiqing Liu; Heqing Huang

doi:10.1371/journal.pone.0043874

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Peer-reviewed

Research Article

Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models

Kaipeng Huang ,

Contributed equally to this work with: Kaipeng Huang, Weihua Liu

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Weihua Liu ,

Contributed equally to this work with: Kaipeng Huang, Weihua Liu

Affiliation Guangzhou Institute of Cardiovascular Disease, The Second Affiliated Hospital of GuangZhou Medical University, Guangzhou, China
⨯
Tian Lan,

Affiliation Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, China
⨯
Xi Xie,

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Jing Peng,

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Juan Huang,

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Shaogui Wang,

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Xiaoyan Shen,

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Peiqing Liu,

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯
Heqing Huang

* E-mail: huangheq@mail.sysu.edu.cn

Affiliation Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
⨯

Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models

Kaipeng Huang,
Weihua Liu,
Tian Lan,
Xi Xie,
Jing Peng,
Juan Huang,
Shaogui Wang,
Xiaoyan Shen,
Peiqing Liu,
Heqing Huang

Published: August 24, 2012
https://doi.org/10.1371/journal.pone.0043874

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