A Comparison of EGFR Mutation Testing Methods in Lung Carcinoma: Direct Sequencing, Real-time PCR and Immunohistochemistry

Bárbara Angulo; Esther Conde; Ana Suárez-Gauthier; Carlos Plaza; Rebeca Martínez; Pilar Redondo; Elisa Izquierdo; Belén Rubio-Viqueira; Luis Paz-Ares; Manuel Hidalgo; Fernando López-Ríos

doi:10.1371/journal.pone.0043842

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Open Access

Peer-reviewed

Research Article

A Comparison of EGFR Mutation Testing Methods in Lung Carcinoma: Direct Sequencing, Real-time PCR and Immunohistochemistry

Bárbara Angulo,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Esther Conde,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Ana Suárez-Gauthier,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Carlos Plaza,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Rebeca Martínez,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Pilar Redondo,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Elisa Izquierdo,

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯
Belén Rubio-Viqueira,

Affiliations Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain, Gastrointestinal Cancer Clinical Research Unit, Spanish National Cancer Research Centre, Madrid, Spain
⨯
Luis Paz-Ares,

Affiliation Department of Oncology, Instituto de Biomedicina de Sevilla (IBIS) & Hospital Universitario Virgen del Rocío, Sevilla, Spain
⨯
Manuel Hidalgo,

Affiliations Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain, Gastrointestinal Cancer Clinical Research Unit, Spanish National Cancer Research Centre, Madrid, Spain
⨯
Fernando López-Ríos

* E-mail: flopezrios@hospitaldemadrid.com

Affiliation Laboratorio de Dianas Terapéuticas, Faculty of Medicine, Centro Integral Oncológico “Clara Campal”, Hospital HM Universitario Sanchinarro, Universidad San Pablo-CEU, Madrid, Spain
⨯

A Comparison of EGFR Mutation Testing Methods in Lung Carcinoma: Direct Sequencing, Real-time PCR and Immunohistochemistry

Bárbara Angulo,
Esther Conde,
Ana Suárez-Gauthier,
Carlos Plaza,
Rebeca Martínez,
Pilar Redondo,
Elisa Izquierdo,
Belén Rubio-Viqueira,
Luis Paz-Ares,
Manuel Hidalgo

Published: August 27, 2012
https://doi.org/10.1371/journal.pone.0043842

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Cancers and neoplasms
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