Pristimerin Causes G1 Arrest, Induces Apoptosis, and Enhances the Chemosensitivity to Gemcitabine in Pancreatic Cancer Cells

Yongwei Wang; Yinan Zhou; Haoxin Zhou; Guang Jia; Ji Liu; Bing Han; Zhuoxin Cheng; Hongchi Jiang; Shangha Pan; Bei Sun

doi:10.1371/journal.pone.0043826

Loading metrics

Open Access

Peer-reviewed

Research Article

Pristimerin Causes G1 Arrest, Induces Apoptosis, and Enhances the Chemosensitivity to Gemcitabine in Pancreatic Cancer Cells

Yongwei Wang ,

Contributed equally to this work with: Yongwei Wang, Yinan Zhou

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Yinan Zhou ,

Contributed equally to this work with: Yongwei Wang, Yinan Zhou

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Haoxin Zhou,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Guang Jia,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Ji Liu,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Bing Han,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Zhuoxin Cheng,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Hongchi Jiang,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Shangha Pan,

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯
Bei Sun

* E-mail: sunbei70@tom.com

Affiliation Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China
⨯

Pristimerin Causes G1 Arrest, Induces Apoptosis, and Enhances the Chemosensitivity to Gemcitabine in Pancreatic Cancer Cells

Yongwei Wang,
Yinan Zhou,
Haoxin Zhou,
Guang Jia,
Ji Liu,
Bing Han,
Zhuoxin Cheng,
Hongchi Jiang,
Shangha Pan,
Bei Sun

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0043826

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pancreatic cancer
Is the Subject Area "Pancreatic cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Cyclins
Is the Subject Area "Cyclins" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Cell cycle inhibitors
Is the Subject Area "Cell cycle inhibitors" applicable to this article?

Thanks for your feedback.