Ribavirin Enhances the Action of Interferon-α against Hepatitis C Virus by Promoting the p53 Activity through the ERK1/2 Pathway

Wei-Liang Liu; Hung-Chih Yang; Wen-Cheng Su; Chih-Chiang Wang; Hui-Ling Chen; Hurng-Yi Wang; Wen-Hung Huang; Ding-Shinn Chen; Ming-Yang Lai

doi:10.1371/journal.pone.0043824

Loading metrics

Open Access

Peer-reviewed

Research Article

Ribavirin Enhances the Action of Interferon-α against Hepatitis C Virus by Promoting the p53 Activity through the ERK1/2 Pathway

Wei-Liang Liu,

Affiliation Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
⨯
Hung-Chih Yang ,

* E-mail: hcyang88@ntu.edu.tw (HCY); mylai@ntu.edu.tw (MYL)

Affiliation Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
⨯
Wen-Cheng Su,

Affiliation Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
⨯
Chih-Chiang Wang,

Affiliation Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
⨯
Hui-Ling Chen,

Affiliation Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
⨯
Hurng-Yi Wang,

Affiliation Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
⨯
Wen-Hung Huang,

Affiliation Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
⨯
Ding-Shinn Chen,

Affiliations Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
⨯
Ming-Yang Lai

* E-mail: hcyang88@ntu.edu.tw (HCY); mylai@ntu.edu.tw (MYL)

Affiliations Graduate Institute of Clinical Medicine, and Department of Internal Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan, Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan
⨯

Ribavirin Enhances the Action of Interferon-α against Hepatitis C Virus by Promoting the p53 Activity through the ERK1/2 Pathway

Wei-Liang Liu,
Hung-Chih Yang,
Wen-Cheng Su,
Chih-Chiang Wang,
Hui-Ling Chen,
Hurng-Yi Wang,
Wen-Hung Huang,
Ding-Shinn Chen,
Ming-Yang Lai

Published: September 4, 2012
https://doi.org/10.1371/journal.pone.0043824

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Antiviral therapy
Is the Subject Area "Antiviral therapy" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Hepatitis C virus
Is the Subject Area "Hepatitis C virus" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.