Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster

Alejandro A. Pezzulo; Emma E. Hornick; Michael V. Rector; Miriam Estin; Anna C. Reisetter; Peter J. Taft; Stephen C. Butcher; A. Brent Carter; J. Robert Manak; David A. Stoltz; Joseph Zabner

doi:10.1371/journal.pone.0043777

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Peer-reviewed

Research Article

Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster

Alejandro A. Pezzulo,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Emma E. Hornick,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Michael V. Rector,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Miriam Estin,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Anna C. Reisetter,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Peter J. Taft,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Stephen C. Butcher,

Affiliation Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
⨯
A. Brent Carter,

Affiliations Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa, United States of America
⨯
J. Robert Manak,

Affiliations Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
⨯
David A. Stoltz,

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Joseph Zabner

* E-mail: joseph-zabner@uiowa.edu

Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯

Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster

Alejandro A. Pezzulo,
Emma E. Hornick,
Michael V. Rector,
Miriam Estin,
Anna C. Reisetter,
Peter J. Taft,
Stephen C. Butcher,
A. Brent Carter,
J. Robert Manak,
David A. Stoltz

Published: August 30, 2012
https://doi.org/10.1371/journal.pone.0043777

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Drosophila melanogaster
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Gut bacteria
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Gene expression
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Oxidative stress
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Gene ontologies
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Superoxides
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