Developmental Heterogeneity in DNA Packaging Patterns Influences T-Cell Activation and Transmigration

Soumya Gupta; Nimi Marcel; Shefali Talwar; Megha Garg; Indulaxmi R.; Lakshmi R. Perumalsamy; Apurva Sarin; G. V. Shivashankar

doi:10.1371/journal.pone.0043718

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Open Access

Peer-reviewed

Research Article

Developmental Heterogeneity in DNA Packaging Patterns Influences T-Cell Activation and Transmigration

Soumya Gupta ,

Contributed equally to this work with: Soumya Gupta, Nimi Marcel, Shefali Talwar

Affiliations National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India, Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore
⨯
Nimi Marcel ,

Contributed equally to this work with: Soumya Gupta, Nimi Marcel, Shefali Talwar

Affiliations National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India, Department of Health Sciences, Manipal University, Manipal, Karnataka, India
⨯
Shefali Talwar ,

Contributed equally to this work with: Soumya Gupta, Nimi Marcel, Shefali Talwar

Affiliations National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India, Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore
⨯
Megha Garg,

Affiliations National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India, Department of Biotechnology, Mysore University, Mysore, Karnataka, India
⨯
Indulaxmi R.,

Affiliation National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India
⨯
Lakshmi R. Perumalsamy,

Affiliation National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India
⨯
Apurva Sarin,

Affiliation National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India
⨯
G. V. Shivashankar

* E-mail: dbsgvs@nus.edu.sg or shiva.gvs@gmail.com

Affiliations National Centre for Biological Sciences, Tata Institute for Fundamental Research, Bangalore, Karnataka, India, Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore
⨯

Developmental Heterogeneity in DNA Packaging Patterns Influences T-Cell Activation and Transmigration

Soumya Gupta,
Nimi Marcel,
Shefali Talwar,
Megha Garg,
Indulaxmi R.,
Lakshmi R. Perumalsamy,
Apurva Sarin,
G. V. Shivashankar

Published: September 5, 2012
https://doi.org/10.1371/journal.pone.0043718

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T cells
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Cell staining
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Chromatin
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Thymocytes
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Gene expression
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Histones
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DNA isolation
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