LPS-Induced Lung Inflammation in Marmoset Monkeys – An Acute Model for Anti-Inflammatory Drug Testing

Sophie Seehase; Hans-Dieter Lauenstein; Christina Schlumbohm; Simone Switalla; Vanessa Neuhaus; Christine Förster; Hans-Gerd Fieguth; Olaf Pfennig; Eberhard Fuchs; Franz-Josef Kaup; Martina Bleyer; Jens M. Hohlfeld; Armin Braun; Katherina Sewald; Sascha Knauf

doi:10.1371/journal.pone.0043709

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Open Access

Peer-reviewed

Research Article

LPS-Induced Lung Inflammation in Marmoset Monkeys – An Acute Model for Anti-Inflammatory Drug Testing

Sophie Seehase,

Affiliations Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, Pathology Unit, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Hans-Dieter Lauenstein,

Affiliations Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, Pathology Unit, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Christina Schlumbohm,

Affiliation Encepharm GmbH, Göttingen, Germany
⨯
Simone Switalla,

Affiliation Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
⨯
Vanessa Neuhaus,

Affiliation Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
⨯
Christine Förster,

Affiliation Institute of Pathology, Klinikum Region Hannover Klinikum Nordstadt, Hannover, Germany
⨯
Hans-Gerd Fieguth,

Affiliation Division of Thoracic Surgery, Klinikum Region Hannover Klinikum Oststadt-Heidehaus, Hannover, Germany
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Olaf Pfennig,

Affiliation Institute of Pathology, Klinikum Region Hannover Klinikum Nordstadt, Hannover, Germany
⨯
Eberhard Fuchs,

Affiliation Encepharm GmbH, Göttingen, Germany
⨯
Franz-Josef Kaup,

Affiliation Pathology Unit, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Martina Bleyer,

Affiliation Pathology Unit, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯
Jens M. Hohlfeld,

Affiliation Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
⨯
Armin Braun,

Affiliation Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
⨯
Katherina Sewald ,

Contributed equally to this work with: Katherina Sewald, Sascha Knauf

* E-mail: sascha.knauf@item.fraunhofer.de (SK); katherina.sewald@item.fraunhofer.de (KS)

Affiliation Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
⨯
Sascha Knauf

Contributed equally to this work with: Katherina Sewald, Sascha Knauf

* E-mail: sascha.knauf@item.fraunhofer.de (SK); katherina.sewald@item.fraunhofer.de (KS)

Affiliations Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany, Pathology Unit, German Primate Center, Leibniz-Institute for Primate Research, Göttingen, Germany
⨯

LPS-Induced Lung Inflammation in Marmoset Monkeys – An Acute Model for Anti-Inflammatory Drug Testing

Sophie Seehase,
Hans-Dieter Lauenstein,
Christina Schlumbohm,
Simone Switalla,
Vanessa Neuhaus,
Christine Förster,
Hans-Gerd Fieguth,
Olaf Pfennig,
Eberhard Fuchs,
Franz-Josef Kaup

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0043709

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