The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

Sandra Marie Schaal; Maneesh Sen Garg; Mousumi Ghosh; Lilie Lovera; Michael Lopez; Monal Patel; Jack Louro; Samik Patel; Luis Tuesta; Wai-Man Chan; Damien Daniel Pearse

doi:10.1371/journal.pone.0043634

Loading metrics

Open Access

Peer-reviewed

Research Article

The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

Sandra Marie Schaal,

Affiliations The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America, The Neuroscience Program, University of Miami, Miami, Florida, United States of America
⨯
Maneesh Sen Garg,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Mousumi Ghosh,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Lilie Lovera,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Michael Lopez,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Monal Patel,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Jack Louro,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Samik Patel,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Luis Tuesta,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Wai-Man Chan,

Affiliation The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Damien Daniel Pearse

* E-mail: DPearse@med.miami.edu

Affiliations The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America, The Neuroscience Program, University of Miami, Miami, Florida, United States of America, The Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, United States of America, The Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯

The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

Sandra Marie Schaal,
Maneesh Sen Garg,
Mousumi Ghosh,
Lilie Lovera,
Michael Lopez,
Monal Patel,
Jack Louro,
Samik Patel,
Luis Tuesta,
Wai-Man Chan

Published: September 19, 2012
https://doi.org/10.1371/journal.pone.0043634

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Spinal cord injury
Is the Subject Area "Spinal cord injury" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Protein folding
Is the Subject Area "Protein folding" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Axons
Is the Subject Area "Axons" applicable to this article?

Thanks for your feedback.