A Single Residue Substitution in the Receptor-Binding Domain of H5N1 Hemagglutinin Is Critical for Packaging into Pseudotyped Lentiviral Particles

Dong-Jiang Tang; Yuen-Man Lam; Yu-Lam Siu; Chi-Hong Lam; Shui-Ling Chu; J. S. Malik Peiris; Philippe Buchy; Béatrice Nal; Roberto Bruzzone

doi:10.1371/journal.pone.0043596

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Open Access

Peer-reviewed

Research Article

A Single Residue Substitution in the Receptor-Binding Domain of H5N1 Hemagglutinin Is Critical for Packaging into Pseudotyped Lentiviral Particles

Dong-Jiang Tang ,

* E-mail: tangd@hkucc.hku.hk

Current address: School of Basic Science, Guangzhou Medical University, Guangzhou, People's Republic of China

Affiliation HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
Yuen-Man Lam,

Affiliation HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
Yu-Lam Siu,

Affiliation HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
Chi-Hong Lam,

Affiliation HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
Shui-Ling Chu,

Affiliation HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
J. S. Malik Peiris,

Affiliations HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China, Center for Influenza Research – School of Public Health, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
Philippe Buchy,

Affiliation Virology Unit, Institut Pasteur in Cambodia, Phnom Penh, Kingdom of Cambodia
⨯
Béatrice Nal,

Current address: Division of Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, United Kingdom

Affiliations HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China, Department of Anatomy, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China
⨯
Roberto Bruzzone

Affiliations HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong, Special Administrative Region, People's Republic of China, Department of Cell Biology and Infection, Institut Pasteur, Paris, France
⨯

A Single Residue Substitution in the Receptor-Binding Domain of H5N1 Hemagglutinin Is Critical for Packaging into Pseudotyped Lentiviral Particles

Dong-Jiang Tang,
Yuen-Man Lam,
Yu-Lam Siu,
Chi-Hong Lam,
Shui-Ling Chu,
J. S. Malik Peiris,
Philippe Buchy,
Béatrice Nal,
Roberto Bruzzone

Published: November 2, 2012
https://doi.org/10.1371/journal.pone.0043596

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