Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

Marilyn E. Carroll; Natalie E. Zlebnik; Justin J. Anker; Thomas R. Kosten; Frank M. Orson; Xiaoyun Shen; Berma Kinsey; Robin J. Parks; Yang Gao; Stephen Brimijoin

doi:10.1371/journal.pone.0043536

Loading metrics

Open Access

Peer-reviewed

Research Article

Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

Marilyn E. Carroll,

Affiliation Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Natalie E. Zlebnik,

Affiliation Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Justin J. Anker,

Affiliation Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, United States of America
⨯
Thomas R. Kosten,

Affiliation Departments of Medicine, Psychiatry & Neuroscience, and Pathology & Immunology, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas, United States of America
⨯
Frank M. Orson,

Affiliation Departments of Medicine, Psychiatry & Neuroscience, and Pathology & Immunology, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas, United States of America
⨯
Xiaoyun Shen,

Affiliation Departments of Medicine, Psychiatry & Neuroscience, and Pathology & Immunology, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas, United States of America
⨯
Berma Kinsey,

Affiliation Departments of Medicine, Psychiatry & Neuroscience, and Pathology & Immunology, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas, United States of America
⨯
Robin J. Parks,

Affiliation Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario Canada
⨯
Yang Gao,

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Stephen Brimijoin

* E-mail: Brimijoin@mayo.edu

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

Marilyn E. Carroll,
Natalie E. Zlebnik,
Justin J. Anker,
Thomas R. Kosten,
Frank M. Orson,
Xiaoyun Shen,
Berma Kinsey,
Robin J. Parks,
Yang Gao,
Stephen Brimijoin

Published: August 17, 2012
https://doi.org/10.1371/journal.pone.0043536

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cocaine
Is the Subject Area "Cocaine" applicable to this article?

Thanks for your feedback.
Biological locomotion
Is the Subject Area "Biological locomotion" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Hydrolases
Is the Subject Area "Hydrolases" applicable to this article?

Thanks for your feedback.
Viral vectors
Is the Subject Area "Viral vectors" applicable to this article?

Thanks for your feedback.
Antibody therapy
Is the Subject Area "Antibody therapy" applicable to this article?

Thanks for your feedback.
Mice
Is the Subject Area "Mice" applicable to this article?

Thanks for your feedback.
Rats
Is the Subject Area "Rats" applicable to this article?

Thanks for your feedback.