N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat

Charalambos Tsagogiorgas; Johannes Wedel; Maximilia Hottenrott; Michael O. Schneider; Uta Binzen; Wolfgang Greffrath; Rolf-Detlef Treede; Bastian Theisinger; Sonja Theisinger; Rüdiger Waldherr; Bernhard K. Krämer; Manfred Thiel; Peter Schnuelle; Benito A. Yard; Simone Hoeger

doi:10.1371/journal.pone.0043525

Loading metrics

Open Access

Peer-reviewed

Research Article

N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat

Charalambos Tsagogiorgas ,

* E-mail: charalambos.tsagogiorgas@medma.uni-heidelberg.de

Affiliation Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Johannes Wedel,

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Maximilia Hottenrott,

Affiliation Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Michael O. Schneider,

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Uta Binzen,

Affiliation Division of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Wolfgang Greffrath,

Affiliation Division of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Rolf-Detlef Treede,

Affiliation Division of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Bastian Theisinger,

Affiliation Novaliq GmbH, Heidelberg, Germany
⨯
Sonja Theisinger,

Affiliation Novaliq GmbH, Heidelberg, Germany
⨯
Rüdiger Waldherr,

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Bernhard K. Krämer,

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Manfred Thiel,

Affiliation Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Peter Schnuelle,

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Benito A. Yard,

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯
Simone Hoeger

Affiliation Department of Medicine V (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
⨯

N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat

Charalambos Tsagogiorgas,
Johannes Wedel,
Maximilia Hottenrott,
Michael O. Schneider,
Uta Binzen,
Wolfgang Greffrath,
Rolf-Detlef Treede,
Bastian Theisinger,
Sonja Theisinger,
Rüdiger Waldherr

Published: August 20, 2012
https://doi.org/10.1371/journal.pone.0043525

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Kidneys
Is the Subject Area "Kidneys" applicable to this article?

Thanks for your feedback.
Dopamine
Is the Subject Area "Dopamine" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Renal system
Is the Subject Area "Renal system" applicable to this article?

Thanks for your feedback.
Renal ischemia
Is the Subject Area "Renal ischemia" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Ischemia
Is the Subject Area "Ischemia" applicable to this article?

Thanks for your feedback.