Human Mesenchymal Stem Cell Expression Program upon Extended Ex-Vivo Cultivation, as Revealed by 2-DE-Based Quantitative Proteomics

Andreia Madeira; Cláudia L. da Silva; Francisco dos Santos; Emilio Camafeita; Joaquim M. S. Cabral; Isabel Sá-Correia

doi:10.1371/journal.pone.0043523

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Peer-reviewed

Research Article

Human Mesenchymal Stem Cell Expression Program upon Extended Ex-Vivo Cultivation, as Revealed by 2-DE-Based Quantitative Proteomics

Andreia Madeira,

Affiliations Institute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Lisboa, Portugal, Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon, Lisboa, Portugal
⨯
Cláudia L. da Silva,

Affiliations Institute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Lisboa, Portugal, Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon, Lisboa, Portugal
⨯
Francisco dos Santos,

Affiliations Institute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Lisboa, Portugal, Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon, Lisboa, Portugal
⨯
Emilio Camafeita,

Affiliation Unidad de Proteómica, Centro Nacional de Investigaciones Cardiovasculares, CNIC, Melchor Fernández Almagro 3, Madrid, Spain
⨯
Joaquim M. S. Cabral,

Affiliations Institute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Lisboa, Portugal, Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon, Lisboa, Portugal
⨯
Isabel Sá-Correia

* E-mail: isacorreia@ist.utl.pt

Affiliations Institute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Lisboa, Portugal, Department of Bioengineering, Instituto Superior Técnico, Technical University of Lisbon, Lisboa, Portugal
⨯

Human Mesenchymal Stem Cell Expression Program upon Extended Ex-Vivo Cultivation, as Revealed by 2-DE-Based Quantitative Proteomics

Andreia Madeira,
Cláudia L. da Silva,
Francisco dos Santos,
Emilio Camafeita,
Joaquim M. S. Cabral,
Isabel Sá-Correia

Published: August 20, 2012
https://doi.org/10.1371/journal.pone.0043523

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Mesenchymal stem cells
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Cytoskeletal proteins
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Heat shock response
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Cell differentiation
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Cytoskeleton
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Transcription factors
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Senescence
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