Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners

Juliette Sage; Emmanuelle Leblanc-Noblesse; Carine Nizard; Takako Sasaki; Sylvianne Schnebert; Eric Perrier; Robin Kurfurst; Dieter Brömme; Gilles Lalmanach; Fabien Lecaille

doi:10.1371/journal.pone.0043494

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Peer-reviewed

Research Article

Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners

Juliette Sage,

Affiliations INSERM, UMR 1100, Pathologies Respiratoires: protéolyse et aérosolthérapie, Centre d’Etude des Pathologies Respiratoires, Tours, France, Université François Rabelais, UMR 1100, Tours, France, Louis Vuitton Moët Hennessy (LVMH-Recherche), Saint Jean de Braye, France
⨯
Emmanuelle Leblanc-Noblesse,

Affiliation Louis Vuitton Moët Hennessy (LVMH-Recherche), Saint Jean de Braye, France
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Carine Nizard,

Affiliations Louis Vuitton Moët Hennessy (LVMH-Recherche), Saint Jean de Braye, France, Laboratoire de Pharmacologie Cellulaire de l’Ecole Pratique des Hautes Etudes, Centre de Recherche des Cordeliers, Paris, France
⨯
Takako Sasaki,

Affiliation Department of Experimental Medicine I, Nikolaus-Fiebiger Center for Molecular Medicine, University of Erlangen-Nuremberg, Erlangen, Germany
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Sylvianne Schnebert,

Affiliation Louis Vuitton Moët Hennessy (LVMH-Recherche), Saint Jean de Braye, France
⨯
Eric Perrier,

Affiliation Louis Vuitton Moët Hennessy (LVMH-Recherche), Saint Jean de Braye, France
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Robin Kurfurst,

Affiliation Louis Vuitton Moët Hennessy (LVMH-Recherche), Saint Jean de Braye, France
⨯
Dieter Brömme,

Affiliation University of British Columbia, Department of Oral Biological and Medical Sciences, Vancouver, British Columbia, Canada
⨯
Gilles Lalmanach,

Affiliations INSERM, UMR 1100, Pathologies Respiratoires: protéolyse et aérosolthérapie, Centre d’Etude des Pathologies Respiratoires, Tours, France, Université François Rabelais, UMR 1100, Tours, France
⨯
Fabien Lecaille

* E-mail: fabien.lecaille@univ-tours.fr

Affiliations INSERM, UMR 1100, Pathologies Respiratoires: protéolyse et aérosolthérapie, Centre d’Etude des Pathologies Respiratoires, Tours, France, Université François Rabelais, UMR 1100, Tours, France
⨯

Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners

Juliette Sage,
Emmanuelle Leblanc-Noblesse,
Carine Nizard,
Takako Sasaki,
Sylvianne Schnebert,
Eric Perrier,
Robin Kurfurst,
Dieter Brömme,
Gilles Lalmanach,
Fabien Lecaille

Published: August 28, 2012
https://doi.org/10.1371/journal.pone.0043494

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Collagens
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Keratinocytes
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Extracellular matrix
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Cysteine
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Proteases
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Extracellular matrix proteins
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Proteolysis
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