Reduced BMP Signaling Results in Hindlimb Fusion with Lethal Pelvic/Urogenital Organ Aplasia: A New Mouse Model of Sirenomelia

• Kentaro Suzuki,

  Affiliations Department of Development of Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera, Wakayama, Japan, Department of Organ Formation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan

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• Yasuha Adachi,

  Affiliations Department of Development of Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera, Wakayama, Japan, Department of Organ Formation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan

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• Tomokazu Numata,

  Affiliations Department of Development of Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera, Wakayama, Japan, Department of Organ Formation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan

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• Shoko Nakada,

  Affiliations Department of Development of Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera, Wakayama, Japan, Department of Organ Formation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan

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• Motoko Yanagita,

  Affiliation Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Naomi Nakagata,

  Affiliation Division of Reproductive Engineering, Center for Animal Resources and Development, Kumamoto University, Kumamoto, Japan

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• Sylvia M. Evans,

  Affiliations Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, United States of America, Department of Medicine, University of California San Diego, La Jolla, California, United States of America

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• Daniel Graf,

  Affiliation Institute of Oral Biology, Faculty of Medicine, University of Zurich, Zurich, Switzerland

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• Aris Economides,

  Affiliation Genome Engineering Technologies, Regeneron Pharmaceuticals, Tarrytown, New York, United States of America

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• Ryuma Haraguchi,

  Affiliation Department of Molecular Pathology, Ehime University Graduate School of Medicine, Ehime, Japan

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• Anne M. Moon,

  Affiliation Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania, United States of America

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• Gen Yamada

  * E-mail: genyama77@yahoo.co.jp

  Affiliations Department of Development of Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera, Wakayama, Japan, Department of Organ Formation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan

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