Placental Transfer of Maternally-Derived IgA Precludes the Use of Guthrie Card Eluates as a Screening Tool for Primary Immunodeficiency Diseases

Stephan Borte; Magdalena Janzi; Qiang Pan-Hammarström; Ulrika von Döbeln; Lennart Nordvall; Jacek Winiarski; Anders Fasth; Lennart Hammarström

doi:10.1371/journal.pone.0043419

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Open Access

Peer-reviewed

Research Article

Placental Transfer of Maternally-Derived IgA Precludes the Use of Guthrie Card Eluates as a Screening Tool for Primary Immunodeficiency Diseases

Stephan Borte ,

* E-mail: stephan.borte@ki.se (SB); lennart.hammarstrom@ki.se (LH)

Affiliations Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden, Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Leipzig, Germany, ImmunoDeficiencyCenter Leipzig (IDCL) at Hospital St. Georg gGmbH Leipzig, Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies Leipzig, Leipzig, Germany
⨯
Magdalena Janzi,

Affiliation Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Qiang Pan-Hammarström,

Affiliation Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Ulrika von Döbeln,

Affiliation Division of Metabolic Diseases, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Lennart Nordvall,

Affiliation Department of Women’s and Children’s Health, Uppsala University, Academic Hospital, Uppsala, Sweden
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Jacek Winiarski,

Affiliation Division of Pediatrics (CLINTEC), Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Anders Fasth,

Affiliation Department of Pediatrics, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
⨯
Lennart Hammarström

* E-mail: stephan.borte@ki.se (SB); lennart.hammarstrom@ki.se (LH)

Affiliation Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯

Placental Transfer of Maternally-Derived IgA Precludes the Use of Guthrie Card Eluates as a Screening Tool for Primary Immunodeficiency Diseases

Stephan Borte,
Magdalena Janzi,
Qiang Pan-Hammarström,
Ulrika von Döbeln,
Lennart Nordvall,
Jacek Winiarski,
Anders Fasth,
Lennart Hammarström

Published: August 16, 2012
https://doi.org/10.1371/journal.pone.0043419

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