Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion

Yeon Ja Choi; Yun Jung Park; Ji Young Park; Hyoung Oh Jeong; Dae Hyun Kim; Young Mi Ha; Ji Min Kim; Yu Min Song; Hyoung-Sam Heo; Byung Pal Yu; Pusoon Chun; Hyung Ryong Moon; Hae Young Chung

doi:10.1371/journal.pone.0043418

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Open Access

Peer-reviewed

Research Article

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion

Yeon Ja Choi,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea
⨯
Yun Jung Park,

Affiliation Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea
⨯
Ji Young Park,

Affiliation Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea
⨯
Hyoung Oh Jeong,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea
⨯
Dae Hyun Kim,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea
⨯
Young Mi Ha,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea
⨯
Ji Min Kim,

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea
⨯
Yu Min Song,

Affiliation Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea
⨯
Hyoung-Sam Heo,

Affiliation Plant Systems Engineering Center, KRIBB, Daejeon, Korea
⨯
Byung Pal Yu,

Affiliation Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Pusoon Chun,

Affiliation College of Pharmacy, Inje University, Gimhae, Gyeongnam, Korea
⨯
Hyung Ryong Moon ,

* E-mail: hyjung@pusan.ac.kr (HYC); mhr108@pusan.ac.kr (HRM)

Affiliation Laboratory of Medicinal Chemistry, College of Pharmacy, Pusan National University, Busan, Korea
⨯
Hae Young Chung

* E-mail: hyjung@pusan.ac.kr (HYC); mhr108@pusan.ac.kr (HRM)

Affiliation Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea
⨯

Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion

Yeon Ja Choi,
Yun Jung Park,
Ji Young Park,
Hyoung Oh Jeong,
Dae Hyun Kim,
Young Mi Ha,
Ji Min Kim,
Yu Min Song,
Hyoung-Sam Heo,
Byung Pal Yu

Published: August 22, 2012
https://doi.org/10.1371/journal.pone.0043418

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Cell fusion
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