Exploiting the MDM2-CK1α Protein-Protein Interface to Develop Novel Biologics That Induce UBL-Kinase-Modification and Inhibit Cell Growth

Open Access

Peer-reviewed

Research Article

Anne-Sophie Huart,

Affiliation p53 Signal Transduction Group, Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
⨯
Nicola J. MacLaine,

Affiliation p53 Signal Transduction Group, Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
⨯
Vikram Narayan,

Affiliation Interferon and Cell Signalling Group, Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
⨯
Ted R. Hupp

* E-mail: ted.hupp@ed.ac.uk

Affiliation p53 Signal Transduction Group, Edinburgh Cancer Research Centre in the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
⨯

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Co-immunoprecipitation
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Small interfering RNA
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Ubiquitination
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Protein-protein interactions
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Cancers and neoplasms
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