Beta-Adrenergic Receptor 1 Selective Antagonism Inhibits Norepinephrine-Mediated TNF-Alpha Downregulation in Experimental Liver Cirrhosis

Pedro Zapater; Isabel Gómez-Hurtado; Gloria Peiró; José Manuel González-Navajas; Irma García; Paula Giménez; Alba Moratalla; José Such; Rubén Francés

doi:10.1371/journal.pone.0043371

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Peer-reviewed

Research Article

Beta-Adrenergic Receptor 1 Selective Antagonism Inhibits Norepinephrine-Mediated TNF-Alpha Downregulation in Experimental Liver Cirrhosis

Pedro Zapater,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Servicio de Farmacología Clínica, Hospital General Universitario, Alicante, Spain
⨯
Isabel Gómez-Hurtado,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯
Gloria Peiró,

Affiliation Unidad de Investigación, Hospital General Universitario, Alicante, Spain
⨯
José Manuel González-Navajas,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯
Irma García,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯
Paula Giménez,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯
Alba Moratalla,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯
José Such,

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯
Rubén Francés

* E-mail: frances_rub@gva.es

Affiliations The Biomedical Research Centre Network in the Area of Hepatic and Digestive Disorders (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain, Unidad Hepática, Hospital General Universitario, Alicante, Spain
⨯

Beta-Adrenergic Receptor 1 Selective Antagonism Inhibits Norepinephrine-Mediated TNF-Alpha Downregulation in Experimental Liver Cirrhosis

Pedro Zapater,
Isabel Gómez-Hurtado,
Gloria Peiró,
José Manuel González-Navajas,
Irma García,
Paula Giménez,
Alba Moratalla,
José Such,
Rubén Francés

Published: August 20, 2012
https://doi.org/10.1371/journal.pone.0043371

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Fibrosis
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