Identification of the Amino Acids 300–600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

• Sabine S. Neukamm,

  Affiliations Division of Clinical Chemistry and Pathobiochemistry, Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen (Paul Langerhans Institute Tuebingen), Member of the German Diabetes Centre (DZD e.V.), Tuebingen, Germany

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• Rachel Toth,

  Affiliation Division of Signal Transduction and Therapy, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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• Nick Morrice,

  Affiliation Beatson Institute for Cancer Research, University of Glasgow, Glasgow, Scotland, United Kingdom

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• David G. Campbell,

  Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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• Carol MacKintosh,

  Affiliation MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom

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• Rainer Lehmann,

  Affiliations Division of Clinical Chemistry and Pathobiochemistry, Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen (Paul Langerhans Institute Tuebingen), Member of the German Diabetes Centre (DZD e.V.), Tuebingen, Germany

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• Hans-Ulrich Haering,

  Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen (Paul Langerhans Institute Tuebingen), Member of the German Diabetes Centre (DZD e.V.), Tuebingen, Germany, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen, Germany

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• Erwin D. Schleicher,

  Affiliations Division of Clinical Chemistry and Pathobiochemistry, Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen (Paul Langerhans Institute Tuebingen), Member of the German Diabetes Centre (DZD e.V.), Tuebingen, Germany

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• Cora Weigert

  * E-mail: Cora.Weigert@med.uni-tuebingen.de

  Affiliations Division of Clinical Chemistry and Pathobiochemistry, Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen, Germany, Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen (Paul Langerhans Institute Tuebingen), Member of the German Diabetes Centre (DZD e.V.), Tuebingen, Germany

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