Validating Serum S100B and Neuron-Specific Enolase as Biomarkers for the Human Brain – A Combined Serum, Gene Expression and MRI Study

Daniel-Paolo Streitbürger; Katrin Arelin; Jürgen Kratzsch; Joachim Thiery; Johann Steiner; Arno Villringer; Karsten Mueller; Matthias L. Schroeter

doi:10.1371/journal.pone.0043284

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Peer-reviewed

Research Article

Validating Serum S100B and Neuron-Specific Enolase as Biomarkers for the Human Brain – A Combined Serum, Gene Expression and MRI Study

Daniel-Paolo Streitbürger ,

* E-mail: paolo@cbs.mpg.de

Affiliation Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
⨯
Katrin Arelin,

Affiliations Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany, Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
⨯
Jürgen Kratzsch,

Affiliation Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
⨯
Joachim Thiery,

Affiliations Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
⨯
Johann Steiner,

Affiliations Department of Psychiatry, University of Magdeburg, Magdeburg, Germany, Pembroke College, University of Cambridge, Cambridge, United Kingdom
⨯
Arno Villringer,

Affiliations Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany, Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
⨯
Karsten Mueller ,

Contributed equally to this work with: Karsten Mueller, Matthias L. Schroeter

Affiliation Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
⨯
Matthias L. Schroeter

Contributed equally to this work with: Karsten Mueller, Matthias L. Schroeter

Affiliations Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, Clinic for Cognitive Neurology, University of Leipzig, Leipzig, Germany, Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany, Consortium for Frontotemporal Lobar Degeneration, Ulm, Germany
⨯

Validating Serum S100B and Neuron-Specific Enolase as Biomarkers for the Human Brain – A Combined Serum, Gene Expression and MRI Study

Daniel-Paolo Streitbürger,
Katrin Arelin,
Jürgen Kratzsch,
Joachim Thiery,
Johann Steiner,
Arno Villringer,
Karsten Mueller,
Matthias L. Schroeter

Published: August 14, 2012
https://doi.org/10.1371/journal.pone.0043284

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