A Mouse with an N-Ethyl-N-Nitrosourea (ENU) Induced Trp589Arg Galnt3 Mutation Represents a Model for Hyperphosphataemic Familial Tumoural Calcinosis

Christopher T. Esapa; Rosie A. Head; Jeshmi Jeyabalan; Holly Evans; Tertius A. Hough; Michael T. Cheeseman; Eugene G. McNally; Andrew J. Carr; Gethin P. Thomas; Matthew A. Brown; Peter I. Croucher; Steve D. M. Brown; Roger D. Cox; Rajesh V. Thakker

doi:10.1371/journal.pone.0043205

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Research Article

A Mouse with an N-Ethyl-N-Nitrosourea (ENU) Induced Trp589Arg Galnt3 Mutation Represents a Model for Hyperphosphataemic Familial Tumoural Calcinosis

Christopher T. Esapa,

Affiliations Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom, Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, United Kingdom
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Rosie A. Head,

Affiliations Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom, Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, United Kingdom
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Jeshmi Jeyabalan,

Affiliation Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom
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Holly Evans,

Affiliation The Mellanby Centre for Bone Research, Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom
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Tertius A. Hough,

Affiliation Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, United Kingdom
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Michael T. Cheeseman,

Affiliation Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, United Kingdom
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Eugene G. McNally,

Affiliation Department of Radiology, Nuffield Orthopaedic Centre and Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom
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Andrew J. Carr,

Affiliation NIHR Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom
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Gethin P. Thomas,

Affiliation University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Australia
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Matthew A. Brown,

Affiliation University of Queensland Diamantina Institute, Princess Alexandra Hospital, University of Queensland, Australia
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Peter I. Croucher,

Affiliations The Mellanby Centre for Bone Research, Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom, Garvan Institute for Medical Research, Sydney, Australia
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Steve D. M. Brown,

Affiliation Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, United Kingdom
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Roger D. Cox,

Affiliation Medical Research Council (MRC) Mammalian Genetics Unit and Mary Lyon Centre, MRC Harwell, Harwell Science and Innovation Campus, United Kingdom
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Rajesh V. Thakker

* E-mail: rajesh.thakker@ndm.ox.ac.uk

Affiliation Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom
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A Mouse with an N-Ethyl-N-Nitrosourea (ENU) Induced Trp589Arg Galnt3 Mutation Represents a Model for Hyperphosphataemic Familial Tumoural Calcinosis

Christopher T. Esapa,
Rosie A. Head,
Jeshmi Jeyabalan,
Holly Evans,
Tertius A. Hough,
Michael T. Cheeseman,
Eugene G. McNally,
Andrew J. Carr,
Gethin P. Thomas,
Matthew A. Brown

Published: August 13, 2012
https://doi.org/10.1371/journal.pone.0043205

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