The Multi-Targeted Kinase Inhibitor Sunitinib Induces Apoptosis in Colon Cancer Cells via PUMA

Jing Sun; Quanhong Sun; Matthew F. Brown; Crissy Dudgeon; Julie Chandler; Xiang Xu; Yongqian Shu; Lin Zhang; Jian Yu

doi:10.1371/journal.pone.0043158

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Open Access

Peer-reviewed

Research Article

The Multi-Targeted Kinase Inhibitor Sunitinib Induces Apoptosis in Colon Cancer Cells via PUMA

Jing Sun ,

Contributed equally to this work with: Jing Sun, Quanhong Sun

Affiliations University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Quanhong Sun ,

Contributed equally to this work with: Jing Sun, Quanhong Sun

Affiliation University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Matthew F. Brown,

Affiliation University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Crissy Dudgeon,

Affiliation University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Julie Chandler,

Affiliation University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Xiang Xu,

Affiliation Research Institute of Surgery and Daping Hospital, The Third Military Medical University, Chongqing, People’s Republic of China
⨯
Yongqian Shu,

Affiliation Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China
⨯
Lin Zhang,

Affiliation University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Jian Yu

* E-mail: yuj2@upmc.edu

Affiliation University of Pittsburgh Cancer Institute, Departments of Pathology, and Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

The Multi-Targeted Kinase Inhibitor Sunitinib Induces Apoptosis in Colon Cancer Cells via PUMA

Jing Sun,
Quanhong Sun,
Matthew F. Brown,
Crissy Dudgeon,
Julie Chandler,
Xiang Xu,
Yongqian Shu,
Lin Zhang,
Jian Yu

Published: August 17, 2012
https://doi.org/10.1371/journal.pone.0043158

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Colorectal cancer
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