Design and Synthesis of Potent N-Acylethanolamine-hydrolyzing Acid Amidase (NAAA) Inhibitor as Anti-Inflammatory Compounds

• Yuhang Li ,

  Contributed equally to this work with: Yuhang Li, Longhe Yang

  Affiliations Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China, Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China

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• Longhe Yang ,

  Contributed equally to this work with: Yuhang Li, Longhe Yang

  Affiliations Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China, Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China

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• Ling Chen,

  Affiliation Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China

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• Chenggang Zhu,

  Affiliation Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China

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• Rui Huang,

  Affiliation Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China

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• Xiao Zheng,

  Affiliation Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China

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• Yan Qiu ,

  * E-mail: fujin@xmu.edu.cn (JF); yanqiu@xmu.edu.cn (YQ)

  Affiliation Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China

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• Jin Fu

  * E-mail: fujin@xmu.edu.cn (JF); yanqiu@xmu.edu.cn (YQ)

  Affiliations Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China, Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy

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