Mig-6 Plays a Critical Role in the Regulation of Cholesterol Homeostasis and Bile Acid Synthesis

Bon Jeong Ku; Tae Hoon Kim; Jae Hee Lee; Eric D. Buras; Lisa D. White; Robert D. Stevens; Olga R. Ilkayeva; James R. Bain; Christopher B. Newgard; Francesco J. DeMayo; Jae-Wook Jeong

doi:10.1371/journal.pone.0042915

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Open Access

Peer-reviewed

Research Article

Mig-6 Plays a Critical Role in the Regulation of Cholesterol Homeostasis and Bile Acid Synthesis

Bon Jeong Ku,

Affiliations Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea
⨯
Tae Hoon Kim,

Affiliation Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, Michigan, United States of America
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Jae Hee Lee,

Affiliation Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, Michigan, United States of America
⨯
Eric D. Buras,

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
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Lisa D. White,

Affiliation Microarray Core Facility, Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
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Robert D. Stevens,

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
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Olga R. Ilkayeva,

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
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James R. Bain,

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
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Christopher B. Newgard,

Affiliation Sarah W. Stedman Nutrition and Metabolism Center, Department of Pharmacology and Cancer Biology and Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Francesco J. DeMayo ,

Contributed equally to this work with: Francesco J. DeMayo, Jae-Wook Jeong

Affiliation Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jae-Wook Jeong

Contributed equally to this work with: Francesco J. DeMayo, Jae-Wook Jeong

* E-mail: JaeWook.Jeong@hc.msu.edu

Affiliation Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, Michigan, United States of America
⨯

Mig-6 Plays a Critical Role in the Regulation of Cholesterol Homeostasis and Bile Acid Synthesis

Bon Jeong Ku,
Tae Hoon Kim,
Jae Hee Lee,
Eric D. Buras,
Lisa D. White,
Robert D. Stevens,
Olga R. Ilkayeva,
James R. Bain,
Christopher B. Newgard,
Francesco J. DeMayo

Published: August 17, 2012
https://doi.org/10.1371/journal.pone.0042915

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Bile
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Cholesterol
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Mouse models
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Chemical synthesis
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Gene expression
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Excretion
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Homeostasis
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Hypercholesterolemia
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