Sex-Specific Regulation of Mitochondrial DNA Levels: Genome-Wide Linkage Analysis to Identify Quantitative Trait Loci

Sonia López; Alfonso Buil; Juan Carlos Souto; Jordi Casademont; John Blangero; Angel Martinez-Perez; Jordi Fontcuberta; Mark Lathrop; Laura Almasy; Jose Manuel Soria

doi:10.1371/journal.pone.0042711

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Peer-reviewed

Research Article

Sex-Specific Regulation of Mitochondrial DNA Levels: Genome-Wide Linkage Analysis to Identify Quantitative Trait Loci

Sonia López,

Affiliation Unit of Genomic of Complex Diseases, Institute of Biomedical Research of Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⨯
Alfonso Buil,

Affiliation Unit of Genomic of Complex Diseases, Institute of Biomedical Research of Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⨯
Juan Carlos Souto,

Affiliation Haemostasis and Thrombosis Unit, Department of Haematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
⨯
Jordi Casademont,

Affiliation Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
⨯
John Blangero,

Affiliation Department of Population Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Angel Martinez-Perez,

Affiliation Unit of Genomic of Complex Diseases, Institute of Biomedical Research of Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⨯
Jordi Fontcuberta,

Affiliation Haemostasis and Thrombosis Unit, Department of Haematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
⨯
Mark Lathrop,

Affiliation Institut de Génomique, Centre National de Génotypage, Evry, France
⨯
Laura Almasy,

Affiliation Department of Population Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Jose Manuel Soria

* E-mail: jsoria@santpau.cat

Affiliation Unit of Genomic of Complex Diseases, Institute of Biomedical Research of Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⨯

Sex-Specific Regulation of Mitochondrial DNA Levels: Genome-Wide Linkage Analysis to Identify Quantitative Trait Loci

Sonia López,
Alfonso Buil,
Juan Carlos Souto,
Jordi Casademont,
John Blangero,
Angel Martinez-Perez,
Jordi Fontcuberta,
Mark Lathrop,
Laura Almasy,
Jose Manuel Soria

Published: August 20, 2012
https://doi.org/10.1371/journal.pone.0042711

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Mitochondrial DNA
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Mitochondria
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Quantitative trait loci
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Linkage analysis
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Single nucleotide polymorphisms
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Polymerase chain reaction
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Genomic signal processing
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