Decreased Serum Levels of Mature Brain-Derived Neurotrophic Factor (BDNF), but Not Its Precursor proBDNF, in Patients with Major Depressive Disorder

Taisuke Yoshida; Masatomo Ishikawa; Tomihisa Niitsu; Michiko Nakazato; Hiroyuki Watanabe; Tetsuya Shiraishi; Akihiro Shiina; Tasuku Hashimoto; Nobuhisa Kanahara; Tadashi Hasegawa; Masayo Enohara; Atsushi Kimura; Masaomi Iyo; Kenji Hashimoto

doi:10.1371/journal.pone.0042676

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Peer-reviewed

Research Article

Decreased Serum Levels of Mature Brain-Derived Neurotrophic Factor (BDNF), but Not Its Precursor proBDNF, in Patients with Major Depressive Disorder

Taisuke Yoshida,

Affiliations Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan, Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Masatomo Ishikawa,

Affiliations Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan, Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Tomihisa Niitsu,

Affiliation Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Michiko Nakazato,

Affiliation Research Center for Child Mental Development, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Hiroyuki Watanabe,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Tetsuya Shiraishi,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Akihiro Shiina,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Tasuku Hashimoto,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Nobuhisa Kanahara,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Tadashi Hasegawa,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Masayo Enohara,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Atsushi Kimura,

Affiliation Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Masaomi Iyo,

Affiliations Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan, Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
⨯
Kenji Hashimoto

* E-mail: hashimoto@faculty.chiba-u.jp

Affiliation Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
⨯

Decreased Serum Levels of Mature Brain-Derived Neurotrophic Factor (BDNF), but Not Its Precursor proBDNF, in Patients with Major Depressive Disorder

Taisuke Yoshida,
Masatomo Ishikawa,
Tomihisa Niitsu,
Michiko Nakazato,
Hiroyuki Watanabe,
Tetsuya Shiraishi,
Akihiro Shiina,
Tasuku Hashimoto,
Nobuhisa Kanahara,
Tadashi Hasegawa

Published: August 3, 2012
https://doi.org/10.1371/journal.pone.0042676

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