Inhibition of p21 Activated Kinase (PAK) Reduces Airway Responsiveness In Vivo and In Vitro in Murine and Human Airways

Wyn C. Hoover; Wenwu Zhang; Zhidong Xue; Huanling Gao; Jonathan Chernoff; D. Wade Clapp; Susan J. Gunst; Robert S. Tepper

doi:10.1371/journal.pone.0042601

Loading metrics

Open Access

Peer-reviewed

Research Article

Inhibition of p21 Activated Kinase (PAK) Reduces Airway Responsiveness In Vivo and In Vitro in Murine and Human Airways

Wyn C. Hoover,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Wenwu Zhang,

Affiliation Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Zhidong Xue,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Huanling Gao,

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Jonathan Chernoff,

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
⨯
D. Wade Clapp ,

Contributed equally to this work with: D. Wade Clapp, Susan J. Gunst, Robert S. Tepper

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Susan J. Gunst ,

Contributed equally to this work with: D. Wade Clapp, Susan J. Gunst, Robert S. Tepper

Affiliation Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Robert S. Tepper

Contributed equally to this work with: D. Wade Clapp, Susan J. Gunst, Robert S. Tepper

* E-mail: rtepper@iupui.edu

Affiliations Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

Inhibition of p21 Activated Kinase (PAK) Reduces Airway Responsiveness In Vivo and In Vitro in Murine and Human Airways

Wyn C. Hoover,
Wenwu Zhang,
Zhidong Xue,
Huanling Gao,
Jonathan Chernoff,
D. Wade Clapp,
Susan J. Gunst,
Robert S. Tepper

Published: August 10, 2012
https://doi.org/10.1371/journal.pone.0042601

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Smooth muscles
Is the Subject Area "Smooth muscles" applicable to this article?

Thanks for your feedback.
Muscle contraction
Is the Subject Area "Muscle contraction" applicable to this article?

Thanks for your feedback.
Trachea
Is the Subject Area "Trachea" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Serotonin
Is the Subject Area "Serotonin" applicable to this article?

Thanks for your feedback.
Acetylcholine
Is the Subject Area "Acetylcholine" applicable to this article?

Thanks for your feedback.
Methacholine challenge
Is the Subject Area "Methacholine challenge" applicable to this article?

Thanks for your feedback.
Respiratory physiology
Is the Subject Area "Respiratory physiology" applicable to this article?

Thanks for your feedback.