The Octadecaneuropeptide ODN Protects Astrocytes against Hydrogen Peroxide-Induced Apoptosis via a PKA/MAPK-Dependent Mechanism

Yosra Hamdi; Hadhemi Kaddour; David Vaudry; Seyma Bahdoudi; Salma Douiri; Jérôme Leprince; Helene Castel; Hubert Vaudry; Marie-Christine Tonon; Mohamed Amri; Olfa Masmoudi-Kouki

doi:10.1371/journal.pone.0042498

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Peer-reviewed

Research Article

The Octadecaneuropeptide ODN Protects Astrocytes against Hydrogen Peroxide-Induced Apoptosis via a PKA/MAPK-Dependent Mechanism

Yosra Hamdi,

Affiliation Laboratory of Functional Neurophysiology and Pathology, Research Unit UR/11ES09, Department of Biological Sciences, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia
⨯
Hadhemi Kaddour,

Affiliation Laboratory of Functional Neurophysiology and Pathology, Research Unit UR/11ES09, Department of Biological Sciences, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia
⨯
David Vaudry,

Affiliations Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, University of Rouen, Mont-Saint-Aignan, France, International Associated Laboratory Samuel de Champlain, Mont-Saint-Aignan, France, Regional Platform for Cell Imaging of Haute-Normandie (PRIMACEN), Institute for Medical Research and Innovation (IRIB), University of Rouen, Mont-Saint-Aignan, France
⨯
Seyma Bahdoudi,

Affiliation Laboratory of Functional Neurophysiology and Pathology, Research Unit UR/11ES09, Department of Biological Sciences, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia
⨯
Salma Douiri,

Affiliation Laboratory of Functional Neurophysiology and Pathology, Research Unit UR/11ES09, Department of Biological Sciences, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia
⨯
Jérôme Leprince,

Affiliations Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, University of Rouen, Mont-Saint-Aignan, France, International Associated Laboratory Samuel de Champlain, Mont-Saint-Aignan, France, Regional Platform for Cell Imaging of Haute-Normandie (PRIMACEN), Institute for Medical Research and Innovation (IRIB), University of Rouen, Mont-Saint-Aignan, France
⨯
Helene Castel,

Affiliation Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, University of Rouen, Mont-Saint-Aignan, France
⨯
Hubert Vaudry ,

* E-mail: mohamed.amri@fst.rnu.tn (MA), hubert.vaudry@univ-rouen.fr (HV)

Affiliations Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, University of Rouen, Mont-Saint-Aignan, France, International Associated Laboratory Samuel de Champlain, Mont-Saint-Aignan, France, Regional Platform for Cell Imaging of Haute-Normandie (PRIMACEN), Institute for Medical Research and Innovation (IRIB), University of Rouen, Mont-Saint-Aignan, France
⨯
Marie-Christine Tonon,

Affiliation Inserm U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation, University of Rouen, Mont-Saint-Aignan, France
⨯
Mohamed Amri ,

* E-mail: mohamed.amri@fst.rnu.tn (MA), hubert.vaudry@univ-rouen.fr (HV)

Affiliation Laboratory of Functional Neurophysiology and Pathology, Research Unit UR/11ES09, Department of Biological Sciences, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia
⨯
Olfa Masmoudi-Kouki

Affiliation Laboratory of Functional Neurophysiology and Pathology, Research Unit UR/11ES09, Department of Biological Sciences, Faculty of Science of Tunis, University Tunis El Manar, Tunis, Tunisia
⨯

The Octadecaneuropeptide ODN Protects Astrocytes against Hydrogen Peroxide-Induced Apoptosis via a PKA/MAPK-Dependent Mechanism

Yosra Hamdi,
Hadhemi Kaddour,
David Vaudry,
Seyma Bahdoudi,
Salma Douiri,
Jérôme Leprince,
Helene Castel,
Hubert Vaudry,
Marie-Christine Tonon,
Mohamed Amri

Published: August 21, 2012
https://doi.org/10.1371/journal.pone.0042498

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Astrocytes
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Apoptosis
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Mitochondria
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Cell death
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Oxidative stress
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Protein kinases
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Glutathione
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Classical mechanics
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