Enhanced ADCC Activity of Affinity Maturated and Fc-Engineered Mini-Antibodies Directed against the AML Stem Cell Antigen CD96

Sahar Mohseni Nodehi; Roland Repp; Christian Kellner; Joachim Bräutigam; Matthias Staudinger; Natalie Schub; Matthias Peipp; Martin Gramatzki; Andreas Humpe

doi:10.1371/journal.pone.0042426

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Peer-reviewed

Research Article

Enhanced ADCC Activity of Affinity Maturated and Fc-Engineered Mini-Antibodies Directed against the AML Stem Cell Antigen CD96

Sahar Mohseni Nodehi ,

Contributed equally to this work with: Sahar Mohseni Nodehi, Roland Repp

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Roland Repp ,

Contributed equally to this work with: Sahar Mohseni Nodehi, Roland Repp

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Christian Kellner,

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Joachim Bräutigam,

Affiliation Department of Structural Biology, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Matthias Staudinger,

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Natalie Schub,

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Matthias Peipp,

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Martin Gramatzki,

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯
Andreas Humpe

* E-mail: a.humpe@med2.uni-kiel.de

Affiliation Division of Stem Cell Transplantation and Immunotherapy, Department of Medicine II, Zoological Institute, Christian-Albrechts-University, Kiel, Germany
⨯

Enhanced ADCC Activity of Affinity Maturated and Fc-Engineered Mini-Antibodies Directed against the AML Stem Cell Antigen CD96

Sahar Mohseni Nodehi,
Roland Repp,
Christian Kellner,
Joachim Bräutigam,
Matthias Staudinger,
Natalie Schub,
Matthias Peipp,
Martin Gramatzki,
Andreas Humpe

Published: August 3, 2012
https://doi.org/10.1371/journal.pone.0042426

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