Estimating Point and Interval Frequency of Antigen-Specific CD4+ T Cells Based on Short In Vitro Expansion and Improved Poisson Distribution Analysis

Open Access

Peer-reviewed

Research Article

Estimating Point and Interval Frequency of Antigen-Specific CD4⁺ T Cells Based on Short In Vitro Expansion and Improved Poisson Distribution Analysis

Giulia Di Lullo,

Affiliations Tumor Immunology Unit, San Raffaele Scientific Institute, Milan, Italy, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
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Francesca Ieva,

Affiliation Laboratorty for Modeling and Scientific Computing (MOX), Dipartimento di Matematica, Politecnico di Milano, Milan, Italy
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Renato Longhi,

Affiliation Consiglio Nazionale delle Ricerche (CNR), Istituto di Chimica del Riconoscimento Molecolare, Milan, Italy
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Anna Maria Paganoni,

Affiliation Laboratorty for Modeling and Scientific Computing (MOX), Dipartimento di Matematica, Politecnico di Milano, Milan, Italy
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Maria Pia Protti

* E-mail: m.protti@hsr.it

Affiliations Tumor Immunology Unit, San Raffaele Scientific Institute, Milan, Italy, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
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T cells
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Cytokines
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Antigen-presenting cells
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Enzyme-linked immunoassays
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Blood
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Statistical distributions
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Viral vaccines
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Immune response
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