Relating the Disease Mutation Spectrum to the Evolution of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Open Access

Peer-reviewed

Research Article

Lavanya Rishishwar ,

Contributed equally to this work with: Lavanya Rishishwar, Neha Varghese

Affiliation School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
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Neha Varghese ,

Contributed equally to this work with: Lavanya Rishishwar, Neha Varghese

Affiliation School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
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Eishita Tyagi,

Affiliation School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
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Stephen C. Harvey,

Affiliation School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
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I. King Jordan,

Affiliations School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America, PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia
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Nael A. McCarty

* E-mail: namccar@emory.edu

Affiliation Department of Pediatrics, Emory University School of Medicine, Center for Cystic Fibrosis Research, Children’s Healthcare of Atlanta, Atlanta, Georgia, United States of America
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Sequence alignment
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Multiple alignment calculation
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Mutation databases
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Evolutionary genetics
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Mutation
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Cystic fibrosis
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Protein domains
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Evolutionary rate
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