3D Multi-isotope Imaging Mass Spectrometry Reveals Penetration of 18O-Trehalose in Mouse Sperm Nucleus

Open Access

Peer-reviewed

Research Article

3D Multi-isotope Imaging Mass Spectrometry Reveals Penetration of ¹⁸O-Trehalose in Mouse Sperm Nucleus

Claude P. Lechene ,

* E-mail: cpl@harvard.edu

Affiliation National Resource for Imaging Mass Spectrometry, Division of Genetics, Harvard Medical School, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
⨯
Gloria Y. Lee,

Affiliation Harvard Medical School, Biomedical Engineering, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
J. Collin Poczatek,

Affiliation National Resource for Imaging Mass Spectrometry, Division of Genetics, Harvard Medical School, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America
⨯
Mehmet Toner,

Affiliation Harvard Medical School, Biomedical Engineering, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
John D. Biggers

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Sperm
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Trehalose
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Sperm head
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Atomic nuclei
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Chromatin
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Genetic engineering
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Nuclear matrix
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Nuclear membrane
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