Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-κB Signaling Pathways

Huan Wang; Yifei Wu; David M. Ojcius; X. Frank Yang; Chenglin Zhang; Shibiao Ding; Xu’ai Lin; Jie Yan

doi:10.1371/journal.pone.0042266

Loading metrics

Open Access

Peer-reviewed

Research Article

Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-κB Signaling Pathways

Huan Wang ,

Contributed equally to this work with: Huan Wang, Yifei Wu

Affiliations Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Yifei Wu ,

Contributed equally to this work with: Huan Wang, Yifei Wu

Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
David M. Ojcius,

Affiliation Health Sciences Research Institute and Molecular Cell Biology, University of California, Merced, California, United States of America
⨯
X. Frank Yang,

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Chenglin Zhang,

Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Shibiao Ding,

Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Xu’ai Lin ,

* E-mail: Med_bp@zju.edu.cn (JY); lxai122@163.com (XL)

Affiliation Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Jie Yan

* E-mail: Med_bp@zju.edu.cn (JY); lxai122@163.com (XL)

Affiliations Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯

Leptospiral Hemolysins Induce Proinflammatory Cytokines through Toll-Like Receptor 2-and 4-Mediated JNK and NF-κB Signaling Pathways

Huan Wang,
Yifei Wu,
David M. Ojcius,
X. Frank Yang,
Chenglin Zhang,
Shibiao Ding,
Xu’ai Lin,
Jie Yan

Published: August 1, 2012
https://doi.org/10.1371/journal.pone.0042266

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Leptospira interrogans
Is the Subject Area "Leptospira interrogans" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Leptospira
Is the Subject Area "Leptospira" applicable to this article?

Thanks for your feedback.
Leptospirosis
Is the Subject Area "Leptospirosis" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Toll-like receptors
Is the Subject Area "Toll-like receptors" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.