Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In Vivo

• Chin-Yu Lai,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• An-Chi Tsai,

  Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Taiwan

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• Mei-Chuan Chen,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Li-Hsun Chang,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Hui-Lung Sun,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Ya-Ling Chang,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Chien-Chih Chen,

  Affiliation Department of Biotechnology, Hungkuang University, Taichung, Taiwan

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• Che-Ming Teng ,

  Contributed equally to this work with: Che-Ming Teng, Shiow-Lin Pan

  * E-mail: cmteng@ntu.edu.tw (CMT); apan0826@nhri.org.tw (SLP)

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Shiow-Lin Pan

  Contributed equally to this work with: Che-Ming Teng, Shiow-Lin Pan

  * E-mail: cmteng@ntu.edu.tw (CMT); apan0826@nhri.org.tw (SLP)

  Affiliation Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Taiwan

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