Combining [11C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts

Qing Cheng; Li Lu; Jonas Grafström; Maria Hägg Olofsson; Jan-Olov Thorell; Erik Samén; Katarina Johansson; Hanna-Stina Ahlzén; Sharon Stone-Elander; Stig Linder; Elias S. J. Arnér; Sel-tag Imaging Project

doi:10.1371/journal.pone.0042151

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Open Access

Peer-reviewed

Research Article

Combining [¹¹C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts

Qing Cheng,

Affiliation Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Li Lu,

Affiliations Karolinska Experimental Research and Imaging Center, Department of Comparative Medicine, Karolinska University Hospital, Stockholm, Sweden, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Jonas Grafström,

Affiliation Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
⨯
Maria Hägg Olofsson,

Affiliation Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
⨯
Jan-Olov Thorell,

Affiliations Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, PET Radiochemistry, Neuroradiology Department, Karolinska University Hospital, Stockholm, Sweden
⨯
Erik Samén,

Affiliations Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, PET Radiochemistry, Neuroradiology Department, Karolinska University Hospital, Stockholm, Sweden
⨯
Katarina Johansson,

Affiliation Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Hanna-Stina Ahlzén,

Affiliation Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Sharon Stone-Elander,

Affiliations Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, PET Radiochemistry, Neuroradiology Department, Karolinska University Hospital, Stockholm, Sweden
⨯
Stig Linder,

Affiliation Department of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden
⨯
Elias S. J. Arnér ,

* E-mail: Elias.Arner@ki.se

Affiliation Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
⨯
Sel-tag Imaging Project

¶Membership of the Sel-tag Imaging Project is provided in the Acknowledgments.
⨯

Combining [¹¹C]-AnxA5 PET Imaging with Serum Biomarkers for Improved Detection in Live Mice of Modest Cell Death in Human Solid Tumor Xenografts

Qing Cheng,
Li Lu,
Jonas Grafström,
Maria Hägg Olofsson,
Jan-Olov Thorell,
Erik Samén,
Katarina Johansson,
Hanna-Stina Ahlzén,
Sharon Stone-Elander,
Stig Linder

Published: August 1, 2012
https://doi.org/10.1371/journal.pone.0042151

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