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Open Access

Peer-reviewed

Research Article

An NQO1-Initiated and p53-Independent Apoptotic Pathway Determines the Anti-Tumor Effect of Tanshinone IIA against Non-Small Cell Lung Cancer

Fang Liu ,

Contributed equally to this work with: Fang Liu, Guo Yu

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Guo Yu ,

Contributed equally to this work with: Fang Liu, Guo Yu

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Guangji Wang ,

* E-mail: guangjiwang@hotmail.com (GW); hhp_770505@yahoo.com.cn (HH)

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Huiying Liu,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Xiaolan Wu,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Qiong Wang,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Miao Liu,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Ke Liao,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Mengqiu Wu,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Xuefang Cheng,

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯
Haiping Hao

* E-mail: guangjiwang@hotmail.com (GW); hhp_770505@yahoo.com.cn (HH)

Affiliation State Key Laboratory of Natural Medicines, Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
⨯

An NQO1-Initiated and p53-Independent Apoptotic Pathway Determines the Anti-Tumor Effect of Tanshinone IIA against Non-Small Cell Lung Cancer

Fang Liu,
Guo Yu,
Guangji Wang,
Huiying Liu,
Xiaolan Wu,
Qiong Wang,
Miao Liu,
Ke Liao,
Mengqiu Wu,
Xuefang Cheng

x

Published: July 27, 2012
https://doi.org/10.1371/journal.pone.0042138

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Apoptosis
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Cancers and neoplasms
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Non-small cell lung cancer
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Mitochondria
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Small interfering RNA
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Cancer treatment
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DNA damage
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Cytotoxicity
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