Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo

Junfang Wu; Giorgi Kharebava; Chunshu Piao; Bogdan A. Stoica; Michael Dinizo; Boris Sabirzhanov; Marie Hanscom; Kelsey Guanciale; Alan I. Faden

doi:10.1371/journal.pone.0042129

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Open Access

Peer-reviewed

Research Article

Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo

Junfang Wu ,

* E-mail: jwu@anes.umm.edu

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Giorgi Kharebava,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Chunshu Piao,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Bogdan A. Stoica,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Michael Dinizo,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Boris Sabirzhanov,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Marie Hanscom,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Kelsey Guanciale,

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯
Alan I. Faden

Affiliation Department of Anesthesiology & Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯

Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo

Junfang Wu,
Giorgi Kharebava,
Chunshu Piao,
Bogdan A. Stoica,
Michael Dinizo,
Boris Sabirzhanov,
Marie Hanscom,
Kelsey Guanciale,
Alan I. Faden

Published: July 25, 2012
https://doi.org/10.1371/journal.pone.0042129

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Apoptosis
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Spinal cord injury
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Neurons
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Cyclins
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Spinal cord
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Neuronal death
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Transfection
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Motor neurons
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