SCN5A Mutations in Brugada Syndrome Are Associated with Increased Cardiac Dimensions and Reduced Contractility

Frans van Hoorn; Maria E. Campian; Anje Spijkerboer; Marieke T. Blom; R. Nils Planken; Albert C. van Rossum; Jacques M T. de Bakker; Arthur A M. Wilde; Maarten Groenink; Hanno L. Tan

doi:10.1371/journal.pone.0042037

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Open Access

Peer-reviewed

Research Article

SCN5A Mutations in Brugada Syndrome Are Associated with Increased Cardiac Dimensions and Reduced Contractility

Frans van Hoorn ,

Contributed equally to this work with: Frans van Hoorn, Maria E. Campian

Affiliation Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Maria E. Campian ,

Contributed equally to this work with: Frans van Hoorn, Maria E. Campian

Affiliation Department of Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Anje Spijkerboer,

Affiliation Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Marieke T. Blom,

Affiliation Department of Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
R. Nils Planken,

Affiliation Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Albert C. van Rossum,

Affiliation Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Jacques M T. de Bakker,

Affiliation Department of Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Arthur A M. Wilde,

Affiliations Department of Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Maarten Groenink,

Affiliations Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Hanno L. Tan

* E-mail: h.l.tan@amc.nl

Affiliations Department of Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯

SCN5A Mutations in Brugada Syndrome Are Associated with Increased Cardiac Dimensions and Reduced Contractility

Frans van Hoorn,
Maria E. Campian,
Anje Spijkerboer,
Marieke T. Blom,
R. Nils Planken,
Albert C. van Rossum,
Jacques M T. de Bakker,
Arthur A M. Wilde,
Maarten Groenink,
Hanno L. Tan

Published: August 2, 2012
https://doi.org/10.1371/journal.pone.0042037

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