Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma

• Chia-Jui Yen,

  Affiliations Institute of Clinical Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan, Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan

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• Yih-Jyh Lin ,

  Contributed equally to this work with: Yih-Jyh Lin, Chia-Sheng Yen, Hung-Wen Tsai

  Affiliation Department of Surgery, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan

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• Chia-Sheng Yen ,

  Contributed equally to this work with: Yih-Jyh Lin, Chia-Sheng Yen, Hung-Wen Tsai

  Affiliation Department of General Surgery, Chi-Mei Medical Center, Tainan, Taiwan

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• Hung-Wen Tsai ,

  Contributed equally to this work with: Yih-Jyh Lin, Chia-Sheng Yen, Hung-Wen Tsai

  Affiliation Department of Pathology, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan

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• Ting-Fen Tsai,

  Affiliation Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan

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• Kwang-Yu Chang,

  Affiliations Institute of Clinical Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan, Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan

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• Wei-Chien Huang,

  Affiliation Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan

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• Pin-Wen Lin,

  Affiliation Department of Surgery, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan

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• Chi-Wu Chiang ,

  * E-mail: ttchang@mail.ncku.edu.tw (T-TC); chiangcw@mail.ncku.edu.tw (C-WC)

  Affiliation Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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• Ting-Tsung Chang

  * E-mail: ttchang@mail.ncku.edu.tw (T-TC); chiangcw@mail.ncku.edu.tw (C-WC)

  Affiliations Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Tainan, Taiwan, Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

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