Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Nabil G. Seidah; Steve Poirier; Maxime Denis; Rex Parker; Bowman Miao; Claudio Mapelli; Annik Prat; Hanny Wassef; Jean Davignon; Katherine A. Hajjar; Gaétan Mayer

doi:10.1371/journal.pone.0041865

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Open Access

Peer-reviewed

Research Article

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Nabil G. Seidah,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Affiliated to the Université de Montréal, Montréal, Québec, Canada
⨯
Steve Poirier,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Affiliated to the Université de Montréal, Montréal, Québec, Canada
⨯
Maxime Denis,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Affiliated to the Université de Montréal, Montréal, Québec, Canada
⨯
Rex Parker,

Affiliation Bristol-Myers Squibb Pharmaceutical R & D, Princeton, New Jersey, United States of America
⨯
Bowman Miao,

Affiliation Bristol-Myers Squibb Pharmaceutical R & D, Princeton, New Jersey, United States of America
⨯
Claudio Mapelli,

Affiliation Bristol-Myers Squibb Pharmaceutical R & D, Princeton, New Jersey, United States of America
⨯
Annik Prat,

Affiliation Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Affiliated to the Université de Montréal, Montréal, Québec, Canada
⨯
Hanny Wassef,

Affiliation Hyperlipidemia and Atherosclerosis, Clinical Research Institute of Montreal, Affiliated to the Université de Montréal, Montréal, Québec, Canada
⨯
Jean Davignon,

Affiliation Hyperlipidemia and Atherosclerosis, Clinical Research Institute of Montreal, Affiliated to the Université de Montréal, Montréal, Québec, Canada
⨯
Katherine A. Hajjar,

Affiliation Department of Cell and Developmental Biology, Weill Cornell Medical College, Cornell University, New York, New York, United States of America
⨯
Gaétan Mayer

* E-mail: gaetan.mayer@icm-mhi.org

Affiliation Laboratory of Molecular Cell Biology, Montreal Heart Institute, Département de Médecine and Département de Pharmacologie, Université de Montréal, Montréal, Québec, Canada
⨯

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Nabil G. Seidah,
Steve Poirier,
Maxime Denis,
Rex Parker,
Bowman Miao,
Claudio Mapelli,
Annik Prat,
Hanny Wassef,
Jean Davignon,
Katherine A. Hajjar

Published: July 27, 2012
https://doi.org/10.1371/journal.pone.0041865

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