Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

Qinlong Liu; Hasibur Rehman; Yanjun Shi; Yasodha Krishnasamy; John J. Lemasters; Charles D. Smith; Zhi Zhong

doi:10.1371/journal.pone.0041834

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Peer-reviewed

Research Article

Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

Qinlong Liu ,

Contributed equally to this work with: Qinlong Liu, Hasibur Rehman

Affiliation Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Hasibur Rehman ,

Contributed equally to this work with: Qinlong Liu, Hasibur Rehman

Affiliation Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Yanjun Shi,

Affiliation Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Yasodha Krishnasamy,

Affiliation Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America
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John J. Lemasters,

Affiliations Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America, Biochemistry & Molecular Biology, and Medical University of South Carolina, Charleston, South Carolina, United States of America, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Charles D. Smith,

Affiliations Apogee Biotechnology Corporation, Hummelstown, Pennsylvania, United States of America, Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Zhi Zhong

* E-mail: zhong@musc.edu

Affiliations Departments of Pharmaceutical & Biomedical Sciences and Medical University of South Carolina, Charleston, South Carolina, United States of America, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

Qinlong Liu,
Hasibur Rehman,
Yanjun Shi,
Yasodha Krishnasamy,
John J. Lemasters,
Charles D. Smith,
Zhi Zhong

Published: July 25, 2012
https://doi.org/10.1371/journal.pone.0041834

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01 Aug 2012
15:16 GMT
Most Recent

Is this an Sphk effect? Posted by hlatim on 01 Aug 2012 at 15:16 GMT

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