Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase

• Mohini S. Ghatge ,

  Contributed equally to this work with: Mohini S. Ghatge, Roberto Contestabile

  Affiliation Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Roberto Contestabile ,

  Contributed equally to this work with: Mohini S. Ghatge, Roberto Contestabile

  Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

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• Martino L. di Salvo,

  Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

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• Jigar V. Desai,

  Affiliation Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Amit K. Gandhi,

  Affiliation Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Christina M. Camara,

  Affiliation Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Rita Florio,

  Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

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• Isabel N. González,

  Affiliations Consiglio Nazionale delle Ricerche, Istituto di Biologia Agroambientale e Forestale, Monterotondo Scalo, Roma, Italy, Institute of Biocomputation and Physics of Complex Systems, Universidad de Zaragoza, Zaragoza, Spain

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• Alessia Parroni,

  Affiliation Istituto Pasteur-Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, Roma, Italy

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• Verne Schirch,

  Affiliation Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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• Martin K. Safo

  * E-mail: msafo@vcu.edu

  Affiliation Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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