TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Orla M. Casey; Lei Fang; Paul G. Hynes; Wassim G. Abou-Kheir; Philip L. Martin; Heather S. Tillman; Gyorgy Petrovics; Hibah O. Awwad; Yvona Ward; Ross Lake; Luhua Zhang; Kathleen Kelly

doi:10.1371/journal.pone.0041668

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Open Access

Peer-reviewed

Research Article

TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Orla M. Casey ,

Contributed equally to this work with: Orla M. Casey, Lei Fang, Paul G. Hynes

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lei Fang ,

Contributed equally to this work with: Orla M. Casey, Lei Fang, Paul G. Hynes

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Paul G. Hynes ,

Contributed equally to this work with: Orla M. Casey, Lei Fang, Paul G. Hynes

¶These authors also contributed equally to this work.

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Wassim G. Abou-Kheir ,

¶These authors also contributed equally to this work.

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Philip L. Martin,

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Heather S. Tillman,

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Gyorgy Petrovics,

Affiliation Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Rockville, Maryland, United States of America
⨯
Hibah O. Awwad,

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yvona Ward,

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ross Lake,

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Luhua Zhang,

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Kathleen Kelly

* E-mail: kellyka@mail.nih.gov

Affiliation Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Orla M. Casey,
Lei Fang,
Paul G. Hynes,
Wassim G. Abou-Kheir,
Philip L. Martin,
Heather S. Tillman,
Gyorgy Petrovics,
Hibah O. Awwad,
Yvona Ward,
Ross Lake

Published: July 30, 2012
https://doi.org/10.1371/journal.pone.0041668

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